Wang, Sheng; Zhang, Fuwu; Yu, Guocan; Wang, Zhantong; Jacobson, Orit; Ma, Ying; Tian, Rui; Deng, Hongzhang; Yang, Weijing; Chen, Zhi-Yi; Chen, Xiaoyuan published an article in 2020, the title of the article was Zwitterionic-to-cationic charge conversion polyprodrug nanomedicine for enhanced drug delivery.Product Details of 574-98-1 And the article contains the following content:
Zwitterionic surface modification is a promising strategy for nanomedicines to achieve prolonged circulation time and thus effective tumor accumulation. However, zwitterion modified nanoparticles suffer from reduced cellular internalization efficiency. A polyprodrug-based nanomedicine with zwitterionic-to-cationic charge conversion ability (denoted as ZTC-NMs) was developed for enhanced chemotherapeutic drug delivery. The polyprodrug consists of pH-responsive poly(carboxybetaine)-like zwitterionic segment and glutathione-responsive camptothecin prodrug segment. The ZTC-NMs combine the advantages of zwitterionic surface and polyprodrug. Compared with conventional zwitterionic surface, the ZTC-NMs can respond to tumor microenvironment and realize ZTC surface charge conversion, thus improve cellular internalization efficiency of the nanomedicines. This ZTC method offers a strategy to promote the drug delivery efficiency and therapeutic efficacy, which is promising for the development of cancer nanomedicines. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Product Details of 574-98-1
The Article related to polyprodrug nanomedicine zwitterionic cationic charge conversion drug delivery, charge conversion, nanomedicine, polyprodrug, triggered drug release, zwitterionic, Placeholder for records without volume info and other aspects.Product Details of 574-98-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary