On November 7, 2019, Wang, Guoqiang; Shen, Ruichao; Granger, Brett; He, Jing; Xing, Xuechao; He, Yong; Long, Jiang; Ma, Jun; Wang, Bin; Or, Yat Sun published a patent.COA of Formula: C9H9BrO3 The title of the patent was Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof. And the patent contained the following:
The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: I which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which is associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-l associated with hepatic steatosis, including non-alc. fatty liver disease (NAFLD) and non-alc. steatohepatitis (NASH). The experimental process involved the reaction of 5-Bromo-2-methoxy-4-methylbenzoic acid(cas: 90326-61-7).COA of Formula: C9H9BrO3
The Article related to tetrazole apoptosis signal regulating kinase 1 inhibitors nafld nash, ask1 mediated liver kidney autoimmune neurodegenerative inflammatory cardiovascular diseases, Pharmacology: Drug Interactions and General Pharmacology and other aspects.COA of Formula: C9H9BrO3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary