Venkat Swamy, Puli’s team published research in Synthetic Communications in 2020 | CAS: 626-40-4

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Synthetic Route of C6H5Br2N

《Amide derivatives of 4-azaindole: design, synthesis, and EGFR targeting anticancer agents》 was written by Venkat Swamy, Puli; Kiran Kumar, Vukoti; Radhakrishnam Raju, Ruddarraju; Venkata Reddy, Regalla; Chatterjee, Anindita; Kiran, Gangarapu; Sridhar, Gattu. Synthetic Route of C6H5Br2N And the article was included in Synthetic Communications in 2020. The article conveys some information:

A series of amide derivatives of azaindole-oxazoles (11a-11n) were designed and synthesized and their structures were confirmed by 1HNMR, 13CNMR and mass spectral anal. Further, these derivatives were screened for their anticancer activity against human cancer cell lines viz; MCF7 (breast), A549 (lung) and A375 (melanoma). In vitro anticancer activity screening indicated that most of the hybrids exhibited potent inhibitory activities in a variety of cancer cell lines. Compounds 11m (I), 11j (II), 11d, 11e, 11f, 11k, 11l and 11n (III; R= 4-OMe; 3,5-diOMe; 3,4,5-triOMe; 4-F; 4-NO2; 4-CN; resp.) each exhibited more potent activity than standard, and compounds I and II exhibited excellent activity in MCF-7 cell line with IC50 values 0.034 and 0.036μM. Moreover, all these compounds were subjected to mol. docking studies on EGFR receptor and the results indicated that two potent compounds I and II strongly bind to protein EGFR (PDB ID: 4hjo). It was found that the energy calculations were in good agreement with the observed IC50 values. The experimental part of the paper was very detailed, including the reaction process of 3,5-Dibromoaniline(cas: 626-40-4Synthetic Route of C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Synthetic Route of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary