On October 29, 2015, Takahashi, Taichi; Umino, Akinori; Iijima, Daisuke; Takamatsu, Hisayuki published a patent.Product Details of 1160653-94-0 The title of the patent was Novel 2-aminopyridine and 2-aminopyrimidine derivatives and medicinal use thereof. And the patent contained the following:
Provided are compounds that exhibit an excellent autotaxin (ATX) inhibitory effect, etc. and are efficacious as a prophylactic or therapeutic agent for diseases in which ATX participates. Compounds represented by general formula I [ring A = cycloalkyl, heterocyclyl, etc.; Z1-Z4 = C, N; R1 = halo, (halo)alkyl, (halo)alkoxy, aryl, etc.; R2, R3 = H, halo, (halo)alkyl, (halo)alkoxy, aryl; R4 = H, alkyl, halo; R5, R6 = H, OH, halo, etc., (linked via O, CO, etc.); L1 = bond, linear alkylene, cycloalkylene, etc] have an excellent ATX inhibitory effect and are useful as a prophylactic or therapeutic agent for ATX-associated diseases, e.g., tumor, obesity, and inflammation. The experimental process involved the reaction of 3-Bromo-2-fluoro-6-methoxybenzaldehyde(cas: 1160653-94-0).Product Details of 1160653-94-0
The Article related to aminopyridine aminopyrimidine preparation autotaxin inhibitor antitumor antiobesity antiinflammation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Product Details of 1160653-94-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary