On September 5, 2021, Singh, Ved Prakash; Dowarah, Jayanta; Marak, Brilliant N.; Sran, Balkaran Singh; Tewari, Ashish Kumar published an article.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Study of the structure-bioactivity of fleximers: synthesis, crystal structure, Hirshfeld surface analysis, and anti-inflammatory assays. And the article contained the following:
Synthesized and natural pyridones/pyridines derivatives exhibiting diverse biol. activities. 2-Pyridone has lactam-lactim tautomerization like thymine and uracil bases. In this study, COX-2 target based series of pyridone/pyridine linked fleximers were designed, synthesized and studied. All analogs binding affinity with COX-2 active site were studied through mol. docking, and anti-inflammatory activity studied by in vivo anal. Weak interactions were studied to find binding sites among analogs through crystal packing, Hirshfeld surface anal. and in silico anal. All the analogs exhibited anti-inflammatory activity, while compound (3) is the most active analog among the series. In contrast, since compound (3) is a pyridine-phthalimide ring-containing analog, the presence of a phthalimide group probably favors anti-inflammatory activity over other types of rings. The results suggested further investigations on compounds as anti-inflammatory prodrugs. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione
The Article related to pyridone pyridine linked fleximer crystal packing hirshfeld surface analysis, Placeholder for records without volume info and other aspects.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary