In 2022,Si, Min; Yan, Jiaqi; Ding, Yongzheng; Huang, Hanmin published an article in Organic & Biomolecular Chemistry. The title of the article was 《Pd-Catalyzed carbonylative lactonization of 2-halidearomatic aldehydes with H2O as a nucleophile》.Name: o-Bromobenzaldehyde The author mentioned the following in the article:
A palladium-catalyzed carbonylative cyclization reaction of 2-halidebenzaldehydes with H2O was described, which provided a strategy for the synthesis of diversely substituted 3,3′-oxyphthalides. Notably, the obtained 3,3′-oxyphthalide could be easily transformed into 3-aryl and alkyl phthalides with excellent efficiency using organozinc reagents under mild reaction conditions. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Name: o-Bromobenzaldehyde)
o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Name: o-BromobenzaldehydeSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary