On July 31, 2021, Sarkar, Anindya; Kankanamalage, Anushka C. Galasiti; Zhang, Qian; Cheng, Heng; Sivaprakasam, Prasanna; Naglich, Joseph; Xie, Chunshan; Gangwar, Sanjeev; Boger, Dale L. published an article.Related Products of 2567-29-5 The title of the article was Synthesis, structure-activity relationship studies and evaluation of a TLR 3/8/9 agonist and its analogues. And the article contained the following:
A comprehensive SAR study of a putative TLR 3/8/9 agonist was conducted. Despite the excitement surrounding the potential of the first small mol. TLR3 agonist with a compound that addnl. displayed agonist activity for TLR8 and TLR9, compound I displayed disappointing activity in our hands, failing to match the potency (EC50) reported and displaying only a low efficacy for the extent of stimulated NF-κB activation and release. The evaluation of >75 analogs of I, many of which constitute minor modifications in the structure, failed to identify any that displayed significant activity and none that exceeded the modest activity found for I. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Related Products of 2567-29-5
The Article related to synthesis structure activity relationship tlr3 tlr8 tlr9 agonist, sar study, tlr agonists, tlr3 agonist, toll-like receptor (tlr), General Organic Chemistry: Synthetic Methods and other aspects.Related Products of 2567-29-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary