Ruan, Qing; Gan, Qianqian; Zhang, Xuran; Fang, Sian; Zhang, Junbo published an article in 2021, the title of the article was Preparation and bioevaluation of novel 99mTc-labeled complexes with a 2-nitroimidazole HYNIC derivative for imaging tumor hypoxia.Recommanded Product: 574-98-1 And the article contains the following content:
To develop novel 99mTc-labeled single-photon emission computed tomog. (SPECT) radiotracers for imaging hypoxia, a novel HYNICNM ligand (6-hydrazinonicotinamide (HYNIC) 2- nitroimidazole derivative)was designed and synthesized. Itwas radiolabeledwith technetium-99musing tricine/trisodiumtriphenylphosphine-3,3′′,3′′-trisulfonate (TPPTS), tricine/sodiumtriphenylphosphine-3-monosulfonate (TPPMS) and tricine as co-ligands to obtain [99mTc]Tc-tricine-TPPTS-HYNICNM, [99mTc]Tc-tricine-TPPMS-HYNICNM, and [99mTc]Tc-(tricine)2-HYNICNM, resp. The three technetium-99m complexes were radiolabeled in one step with a high yield (95%) and had good stability in saline and mouse serum. In vitro cellular uptake results showed that these complexes exhibited good hypoxic selectivity. The partition coefficient indicated that they were good hydrophilic complexes, and [99mTc]Tc-tricine-TPPTS-HYNICNM displayed the highest hydrophilicity (-3.02 ± 0.08). The biodistribution in mice bearing S180 tumors showed that [99mTc]Tc-tricine-TPPTS-HYNICNM exhibited higher tumor uptake (1.05 ± 0.27% IA/g); more rapid clearance from the liver, blood, muscle, and other non-target organs; and a higher tumor/non-target ratio, especially for the tumor/liver ratio (1.95), than [99mTc]Tc-tricine-TPPMS-HYNICNM and [99mTc]Tc-(tricine)2-HYNICNM. The results of single-photon emission computed tomog. (SPECT) imaging studies of [99mTc]Tctricine-TPPTS-HYNICNM were in accordance with the biodistribution results, which suggested that [99mTc]Tc-tricine-TPPTS-HYNICNM is a promising agent for imaging tumor hypoxia. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Recommanded Product: 574-98-1
The Article related to nitroimidazole technetium hydrazinonicotinamide tumor hypoxia imaging, 2-nitroimidazole, hynic, hypoxia, technetium-99m, tumor, Placeholder for records without volume info and other aspects.Recommanded Product: 574-98-1
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