On June 12, 2020, Ongwae, George M.; Morrison, Kelly R.; Allen, Ryan A.; Kim, Seonghoon; Im, Wonpil; Wuest, William M.; Pires, Marcos M. published an article.Quality Control of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Broadening Activity of Polymyxin by Quaternary Ammonium Grafting. And the article contained the following:
Bacterial pathogens continue to impose a tremendous health burden across the globe. Here, we describe a novel series of polymyxin-based agents grafted with membrane-active quaternary ammonium warheads to combine two important classes of Gram-neg. antimicrobial scaffolds. The goal was to deliver a targeted quaternary ammonium warhead onto the surface of bacterial pathogens using the outer membrane homing properties of polymyxin. The most potent agents resulted in new scaffolds that retained the ability to target Gram-neg. bacteria and had limited toxicity toward mammalian cells. We showed, using a mol. dynamics approach, that the new agents retained their ability to engage in specific interactions with lipopolysaccharide mols. Significantly, the combination of quaternary ammonium and polymyxin widens the activity to the pathogen Staphylococcus aureus. Our results serve as an example of how two membrane-active agents can be combined to produce a class of novel scaffolds with potent biol. activity. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Quality Control of 4-(Bromomethyl)-1,1′-biphenyl
The Article related to polymyxin quaternary ammonium grafting antibiotic, antibiotic, colistin, membrane, polymyxin, quarternary ammonium, Placeholder for records without volume info and other aspects.Quality Control of 4-(Bromomethyl)-1,1′-biphenyl
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary