《Synthesis of steroid analogs of tubuloclustin, their cytotoxicity and effect on microtubules of A549 carcinoma cells》 was written by Nurieva, E. V.; Zefirov, N. A.; Mamaeva, A. V.; Wobith, B.; Kuznetsov, S. A.; Zefirova, O. N.. Reference of 8-Bromooctanoic acidThis research focused ontubuloclustin methoxyestradiol analog preparation antitumor microtubule lung carcinoma. The article conveys some information:
Synthesis of analogs of tubuloclustin (N-(7-adamant-2-yloxy-7-oxoheptanoyl)-N-deacetylcolchicine ) with the colchicine fragment replaced with 2-methoxyestradiol scaffold attached via phenolic hydroxy group was described. Esters 3a-c exhibit moderate cytotoxicity (EC50 = 5-6 μmol L-1) and exert a weak effect on the microtubule network in A549 human lung carcinoma cells similar to the clustering effect of tubuloclustin and its derivatives Conjugates 6a-c and 7a-c with the phenolic ester bond are low stable and compounds 7a-c are inactive to the microtubules of A549 cells, while compounds 6a-c cause an unusual effect of curling of the microtubules. In the experimental materials used by the author, we found 8-Bromooctanoic acid(cas: 17696-11-6Reference of 8-Bromooctanoic acid)
8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.Reference of 8-Bromooctanoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary