On July 17, 2014, Li, Yun-Long; Burns, David M.; Feng, Hao; Xue, Chu-Biao; Wang, Anlai; Pan, Jun published a patent.HPLC of Formula: 1196157-51-3 The title of the patent was Preparation of bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors for treating proliferative and immune disorders. And the patent contained the following:
The present disclosure describes bicyclic aromatic carboxamide derivatives of formula I (wherein Cy is (un)substituted C3-7 cycloalkyl or (un)substituted 4-10 membered heterocycloalkyl; A1 is N or (un)substituted CH; R2 is H, halogen, C1-6 alkyl, etc.; or A1 and R2 together form part of a ring; R3 is H, halogen or NH2; R4 is H or halogen; and A5-A8 are independently N or (un)substituted CH, with provisos), as well as their compositions and methods of use as Pim kinase inhibitors for treating cancer and other diseases. Synthetic procedures for preparing I are exemplified. Example compound II was prepared in a 6-step synthesis that involved reaction of intermediate III with benzyl [(3S)-1-(3-aminopyridin-4-yl)piperidin-3-yl]carbamate followed by deprotection of the intermediate formed to give II. In Pim kinase inhibitory assays in vitro, II had IC50 values of ≤100 nM for Pim1 and Pim3 and an IC50 value between 100 nM and 1000 nM for Pim2 kinase. The experimental process involved the reaction of 2-Amino-6-bromonicotinic acid(cas: 1196157-51-3).HPLC of Formula: 1196157-51-3
The Article related to preparation bicyclic aromatic carboxamide compound pim kinase inhibitor therapy, proliferative immune disorder treatment bicyclic aromatic carboxamide compound, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 1196157-51-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary