On October 1, 2020, Komandla, Mallareddy; Miura, Joanne; Wang, Haixia; Wang, Xiaolun; Lawson, John David; Tyhonas, John published a patent.COA of Formula: C9H9BrO3 The title of the patent was 2-oxo-2,3-dihydro-1H-imidazo[4,5-B]pyridin-6-yl)-4-methylbenzamide derivatives and related heterocycles as RIPK2 inhibitors for the treatment of autoimmune and other diseases. And the patent contained the following:
The invention relates to preparation of dihydroimidazopyridine benzamides(I) and related heterocycles, and pharmaceutically acceptable salts thereof, as RIPK2 inhibitors. Compounds I wherein α is a single bond; β is a double bond; R2 is oxo; R3 is C1-6 alkyl; R4, R5, R6, R7 and R8 each independently is H, halo, C1-4 alkyl, etc.; R9 is C1-6 alkyl, C3-8 haloalkyl, C2-8 heteroalkyl, etc.; etc., are claimed. The example compound II was prepared from the intermediates(also prepared), (procedure given). Compounds I were evaluated for their biol. activities (data given). Compounds I are receptor-interacting protein kinase 2 (RIPK2) inhibitors and can be useful for treating e.g. type I hypersensitivity reactions, autoimmune diseases, inflammatory disorders, cancer and non-malignant proliferative disorders, such as e.g. allergic rhinitis, asthma, atopic dermatitis, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, lupus nephritis, psoriasis, immune thrombocytopenic purpura, inflammatory bowel disease, chronic obstructive pulmonary disease, Sjogren’s syndrome, ankylosing spondylitis, Behcet’s disease, graft vs. host disease, pemphigus vulgaris, idiopathic plasmacytic lymphadenopathy, atherosclerosis, myocardial infarction and thrombosis. The experimental process involved the reaction of 5-Bromo-2-methoxy-4-methylbenzoic acid(cas: 90326-61-7).COA of Formula: C9H9BrO3
The Article related to dihydroimidazopyridine benzamide preparation ripk2 inhibitor autoimmune disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.COA of Formula: C9H9BrO3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary