On September 24, 2015, Kancharla, Papireddy; Kelly, Jane Xu; Reynolds, Kevin A. published an article.Application In Synthesis of 4-Bromo-3,5-dimethyl-1H-pyrrole-2-carbaldehyde The title of the article was Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials. And the article contained the following:
Synthesis and antimalarial activity of 94 novel bipyrrole tambjamines (TAs) and a library of B-ring functionalized tripyrrole prodiginines (PGs) against a panel of Plasmodium falciparum strains are described. The activity and structure-activity relationships demonstrate that the ring-C of PGs can be replaced by an alkylamine, providing for TAs with retained/enhanced potency. Furthermore, ring-B of PGs/TAs can be substituted with short alkyl substitutions at either 4-position (replacement of OMe) or 3- and 4-positions without impacting potency. Eight representative TAs and two PGs have been evaluated for antimalarial activity against multidrug-resistant P. yoelii in mice in the dose range of 5-100 mg/kg × 4 days by oral administration. The KAR425 TA (I) offered greater efficacy than previously observed for any PG, providing 100% protection to malaria-infected mice until day 28 at doses of 25 and 50 mg/kg × 4 days, and was also curative in this model in a single oral dose (80 mg/kg). This study presents the first account of antimalarial activity in tambjamines. The experimental process involved the reaction of 4-Bromo-3,5-dimethyl-1H-pyrrole-2-carbaldehyde(cas: 89909-51-3).Application In Synthesis of 4-Bromo-3,5-dimethyl-1H-pyrrole-2-carbaldehyde
The Article related to antimalarial tambjamine prodiginine preparation sar, Alkaloids: Alkaloids Containing Three Or More Nitrogen Atoms and other aspects.Application In Synthesis of 4-Bromo-3,5-dimethyl-1H-pyrrole-2-carbaldehyde
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary