On May 15, 2019, Hochegger, Patrick; Faist, Johanna; Seebacher, Werner; Saf, Robert; Maeser, Pascal; Kaiser, Marcel; Weis, Robert published an article.Recommanded Product: 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity. And the article contained the following:
The substitution of 6-fluoroquinolines was modified in ring positions 2 and 4. The new compounds were tested in vitro for their activities against a sensitive and a multidrug resistant strain of Plasmodium falciparum. Some physicochem. parameters were calculated (log P, log D, ligand efficiency) or determined exptl. (permeability). The most promising compounds were tested for their in vivo activity against Plasmodium berghei in a mouse model. The 6-fluoro-2-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-N-[2-(pyrrolidin-1-yl)ethyl]quinoline-4-carboxamide possessed proper physicochem. properties and showed high antiplasmodial activity in vitro (IC50 ≤ 0.0029 μM) and in vivo (99.6% activity). The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Recommanded Product: 2-(2-Bromoethyl)isoindoline-1,3-dione
The Article related to preparation structure fluoroquinoline derivative antiplasmodial malaria, antimalarial, plasmodium berghei, plasmodium falciparum, quinoline derivatives, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 2-(2-Bromoethyl)isoindoline-1,3-dione
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary