On December 31, 2022, Heo, Jinyeong; Koh, Dahae; Woo, Minjeong; Kwon, Doyoon; de Almeida Falcao, Virginia Carla; Wood, Connor; Lee, Honggun; Kim, Kideok; Choi, Inhee; Jang, Jichan; Brodin, Priscille; Shum, David; Delorme, Vincent published an article.COA of Formula: C10H8BrNO2 The title of the article was A combination screening to identify enhancers of para-aminosalicylic acid against Mycobacterium tuberculosis. And the article contained the following:
Para-aminosalicylic acid (PAS) is an antibiotic that was largely used for the multi-therapy of tuberculosis in the twentieth century. To try to overcome the inconvenience of its low efficacy and poor tolerance, we searched for novel chem. entities able to synergize with PAS using a combination screening against growing axenic Mycobacterium tuberculosis. The screening was performed at a sub-inhibitory concentration of PAS on a library of about 100,000 small mols. Selected hit compounds were analyzed by dose-response and further probed with an intracellular macrophage assay. Scaffolds with potential additive effect with PAS are reported, opening interesting prospects for mechanism of action studies. We also report here evidence of a yet unknown bio-activation mechanism, involving activation of pyrido[1,2-a]pyrimidin-4-one (PP) derivatives through the Rv3087 protein. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).COA of Formula: C10H8BrNO2
The Article related to mycobacterium tuberculosis paraaminosalicylic acid combination screening, Placeholder for records without volume info and other aspects.COA of Formula: C10H8BrNO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary