In 2018,Journal of Medicinal Chemistry included an article by Hao, Meixi; Hou, Siyuan; Xue, Lingjing; Yuan, Haoliang; Zhu, Lulu; Wang, Cong; Wang, Bin; Tang, Chunming; Zhang, Can. Computed Properties of C4H7BrO2. The article was titled 《Further Developments of the Phenyl-Pyrrolyl Pentane Series of Nonsteroidal Vitamin D Receptor Modulators as Anticancer Agents》. The information in the text is summarized as follows:
The vitamin D3 receptor (VDR), which belongs to the nuclear-receptor superfamily, is a potential mol. target for anticancer-drug discovery. In this study, a series of nonsteroidal vitamin D mimics with phenyl-pyrrolyl pentane skeletons with therapeutic potentials in cancer treatment were synthesized. Among them, 11b (N-(3-(diethylamino)propyl)-1-ethyl-5-(3-(4-((3-ethyl-3-hydroxypentyl)oxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxamide) and 11g (1-ethyl-5-{1-ethyl-1-[4-(3-ethyl-3-hydroxypentyloxy)-3-methylphenyl]propyl}-1H-pyrrole-2-carboxylic acid (3-morpholin-4-yl-propyl)amide) were identified as the most effective agents in reducing the viability of four cancer-cell lines, particularly those of breast-cancer cells, with IC50 values in the submicromolar-concentration range. In addition, 11b and 11g possessed VDR-binding affinities and displayed significant partial VDR-agonistic activities determined by dual-luciferase-reporter assays and human-leukemia-cell-line (HL-60)-differentiation assays. Furthermore, 11b and 11g inhibited tumor growth in an orthotopic breast-tumor model via inhibition of cell proliferation and induction of cell apoptosis. More importantly, 11b and 11g exhibited favorable pharmacokinetic behavior in vivo and did not increase serum calcium levels or cause any other apparent side effects. In summary, 11b and 11g act as novel VDR modulators and may be promising candidates for cancer chemotherapy. In the experimental materials used by the author, we found Methyl 3-bromopropanoate(cas: 3395-91-3Computed Properties of C4H7BrO2)
Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C4H7BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary