On July 21, 2022, Garofalo, Albert W.; Schwarz, Jacob Bradley; Sabbatini, Fabio Maria; Migliore, Marco; Bernardi, Silvia; Budassi, Federica published a patent.Related Products of 1427433-22-4 The title of the patent was Preparation of indazoles and azaindazoles as LRRK2 inhibitors. And the patent contained the following:
The present invention is directed to indazole and azaindazole derivatives I and II [A = (un)substituted aryl, cycloalkyl, 5-14 membered heteroaryl, etc.; L = O or NH; ring B = Ph or 6-membered heteroaryl; ring C = Ph or 6-membered heteroaryl, wherein ring C is fused to ring D; X2 = N or CR2; X3 = N or CR3; X4 = N or CR4; wherein not more than two of X2, X3, and X4 are simultaneously N; each R1 and R5 = (independently) H, halo, alkyl, etc.; R2-R4 = (independently) H, halo, alkyl, etc.; n = 0-3; m = 0-1; p = 0-3; wherein in I: when ring B = Ph, then n = 1-3 and R1 = group other than H] or pharmaceutically acceptable salts thereof which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders such as Parkinson’s disease. E.g., a multi-step synthesis of III, starting from 6-bromo-1H-indazole and 1-cyclopropyl-4-iodopyrazole, was described. Exemplified compounds I and II were tested in the LRRK2 kinase activity assay (data given). Pharmaceutical composition comprising compound I or II was disclosed. The experimental process involved the reaction of 3-Bromo-2-fluoro-6-methyl-benzoic acid(cas: 1427433-22-4).Related Products of 1427433-22-4
The Article related to indazole azaindazole preparation lrrk2 inhibitor cns disorder parkinson disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Related Products of 1427433-22-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary