On June 18, 2015, Deligny, Michaeel Louis Robert; Heer, Jag Paul; Jackson, Victoria Elizabeth; Kroeplien, Boris; Lecomte, Fabien Claude; Porter, John Robert published a patent.Reference of 3-Bromo-2-fluoro-6-methoxybenzaldehyde The title of the patent was Imidazopyridine derivatives as modulators of TNF activity and their preparation. And the patent contained the following:
A series of substituted 3H-imidazo[4,5-b]pyridine derivatives of formula I, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurol. and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncol. disorders. Compounds of formula I wherein E is a bond, SO2 and NH and derivatives; Q is a bond, O, S, SO, SO2, etc.; Y is (un)substituted C3-7 cycloalkyl, (un)substituted aryl, (un)substituted C3-7 heterocycloalkyl, and (un)substituted heteroaryl; Z is H, halo, CF3, C1-6 alkyl, etc.; R1, R2 and R3 are independently H, halo, CN, NO2, OH, CF3, etc.; R5 is (un)substituted C1-5 alkyl; and N-oxides, pharmaceutically acceptable salts, solvates, glucuronide derivatives, and co-crystals thereof, are claimed. Example compound II was prepared by cyclocondensation of 6-chloro-N2-[(2,5-dichlorophenyl)methyl]pyridine-2,3-diamine with 2-(4-carbamoylphenoxy)acetic acid. The invention compounds were evaluated for their TNFα modulatory activity (some data given). The experimental process involved the reaction of 3-Bromo-2-fluoro-6-methoxybenzaldehyde(cas: 1160653-94-0).Reference of 3-Bromo-2-fluoro-6-methoxybenzaldehyde
The Article related to imidazopyridine preparation tnfalpha modulator, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 3-Bromo-2-fluoro-6-methoxybenzaldehyde
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary