On August 25, 2005, Bouerat, Laeetitia; Fensholdt, Jef; Liang, Xifu; Havez, Sophie; Nielsen, Simon F.; Hansen, Jens R.; Bolvig, Simon; Andersson, Christina published an article.Product Details of 89909-51-3 The title of the article was Indolin-2-ones with High in Vivo Efficacy in a Model for Multiple Sclerosis. And the article contained the following:
The known KDR inhibitor SU5416 and several analogs of the indolin-2-one family were surprisingly found to be highly efficacious in the EAE model, an established model for multiple sclerosis. The high in vivo effect could be correlated to in vitro inhibition of the pro-inflammatory cytokine IL-2. Activity following po administration was obtained with several analogs and via the use of prodrugs. The experimental process involved the reaction of 4-Bromo-3,5-dimethyl-1H-pyrrole-2-carbaldehyde(cas: 89909-51-3).Product Details of 89909-51-3
The Article related to indolinone multiple sclerosis sar preparation derivative antiinflammatory, Pharmacology: Structure-Activity and other aspects.Product Details of 89909-51-3
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