On July 19, 2018, Blagg, Brian S. J.; Kent, Caitlin Nicole; Mishra, Sanket Jaiprakash; Khandelwal, Anuj published a patent.Related Products of 39503-58-7 The title of the patent was Preparation of isoindolin-2-ylmethanone compounds as Hsp90b selective inhibitors for treatment of cancer. And the patent contained the following:
Provided are compounds of formula I as well as compositions including such compounds useful for the treatment of cancers such as non-small cell lung cancer, bladder cancer, or colon cancer. I [wherein each X independently = H, halo, sulfoxide, sulfone, etc.; R1 = H, OH, C1-3 alkyl, etc.; R2 = CH2X5 or OH; X5 = OH, halo, CN, etc.; R3 = alkyl, -CH(CH3)2, CF3, etc.] or a pharmaceutically acceptable salt and/or solvate thereof, are claimed and exemplified. Example compound II was prepared from a multistep procedure (preparation given). Exemplified I was evaluated for antiproliferative activity in cancer cell lines with II demonstrating IC50 values as low as 6.74 ± 1.1 μM in NCI-H23 non-small cell lung cancer cells. The experimental process involved the reaction of Methyl 5-bromo-2-methoxy-4-methylbenzoate(cas: 39503-58-7).Related Products of 39503-58-7
The Article related to isoindolinylmethanone compound preparation hsp90b inhibitor cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Related Products of 39503-58-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary