On May 31, 2022, Zhang, Naichen; Ye, Yuanzhi; Bai, Lu; Liu, Jingjing; Wang, Han; Luan, Xinjun published an article.Safety of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Transition metal-free dearomatization of halonaphthols with C(sp3)-electrophiles. And the article contained the following:
The first intermol. electrophilic dearomatization of halonaphthols I (R1 = H, 7-MeO, 6-Me3Si, 3-Cl, etc.) with benzyl/allyl bromides R2Br (R2 = PhCH2, PhCHMe, 4-MeO2CC6H4CH2, H2C:CHCH2, PhCH:CH, etc.) is described. Halonaphthols are used as carbon nucleophiles in dearomatization to form three-dimensional cyclic enones II with excellent chemoselectivity, in which etherification of phenolic hydroxyl group could be restrained by using cesium carbonate as the base. A wide range of cyclic enones was directly prepared from various substituted benzyl/allyl bromides and halonaphthols. Mechanistic investigations suggest a direct SN2 reaction pathway. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Safety of 4-(Bromomethyl)-1,1′-biphenyl
The Article related to allylic bromide fluoronaphthol chemoselective electrophilic allylation dearomatization, allyl benzyl fluoro naphthalenone preparation, fluoronaphthol chemoselective electrophilic benzylation benzyl bromide dearomatization and other aspects.Safety of 4-(Bromomethyl)-1,1′-biphenyl
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary