Organic compounds having carbon bonded to bromine are called organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Electric Literature of 70-23-5.
Yu, Ya’nan;Han, Yuqiao;Zhang, Fupo;Gao, Zhenmei;Zhu, Tong;Dong, Suzhen;Ma, Mingliang research published 《 Design, Synthesis, and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors》, the research content is summarized as follows. A series of imidazo[1,2-a]pyridine derivatives I [X = 2,4-F2C6H3SO2NH; R1 = Me2NCH2CH2, 2-HOC6H4, 2-(pyrrolidin-1-yl)ethyl, etc.], II [X as above; R2 = Me2NCH2CH2, 2-(4-methylpiperazin-1-yl)ethyl, 2-(morpholin-4-yl)ethyl, 3-(morpholin-4-yl)propyl] and III [R3 = Me2NCH2CH2, 3-HO2CC6H4, 2-thienyl, etc.; R4 = H, Cl, OMe; R5 = NH2, NHSO2Me, 2,4-F2C6H3SO2NH, etc.] was synthesized as phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors and subjected to pharmacokinetics, pharmacodynamics, mol. docking and antitumor activity assessment in vitro and in vivo. Result showed that, the compound III [R3 = 2-(4-methylpiperazin-1-yl)ethyl; R4 = OMe; R5 = 2,4-F2C6H3SO2NH] proved to be a potent PI3K/mTOR dual inhibitor with excellent mTOR kinase selectivity, modest plasma clearance and acceptable oral bioavailability. Furthermore, this compound displayed significant inhibition of tumor growth in HCT116 and HT-29 xenografts without obvious effect on body weight
70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.
Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.
Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Electric Literature of 70-23-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary