On April 30, 2019, Xie, Ruliang; Mei, Xiangdong; Ning, Jun published an article.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Design, synthesis and insecticide activity of novel acetylcholinesterase inhibitors: triazolinone and phthalimide heterodimers. And the article contained the following:
A new series of 1,2,4-triazolin-3-one and phthalimide heterodimers I [X = (CH2)n; n = 1, 2, 9, etc.] was synthesized and evaluated for their insecticidal and acetylcholinesterase inhibitory activities. Most of the synthesized compounds I showed good in vitro inhibitory activities against both Drosophila melanogaster acetylcholinesterase (DmAChE) and Musca domestica acetylcholinesterase (MdAChE). Among them, compound I (n = 7) was found to be most potent AChE inhibitor (IC50 = 8.07 μM to DmAChE, IC50 = 32.24 μM to MdAChE), whose activities were 2.31- and 1.35-fold more active than the pos. control ethion (CP, IC50 = 18.62 μM to DmAChE, IC50 = 43.56 μM to MdAChE). The docking model study revealed that compound I (n = 7) possessed fitted spatial structure and bound to central pocket and peripheral site of DmAChE. Moreover, most of the compounds I demonstrated high insecticidal activity to Lipaphis erysimi and Tetranychus cinnabarinus at concentration of 300 mg/L. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione
The Article related to triazolyl isoindoline dione preparation insecticide acetylcholinesterase inhibitor mol docking, acetylcholinesterase, acetylcholinesterase inhibiting potency, dual binding site, heterodimer, insecticidal activity and other aspects.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary