On May 21, 2021, Weis, Erik; Hayes, Martin A.; Johansson, Magnus J.; Martin-Matute, Belen published an article.Application of 1427433-22-4 The title of the article was Iridium-catalyzed C-H methylation and d3-methylation of benzoic acids with application to late-stage functionalizations. And the article contained the following:
An iridium-catalyzed carboxylate-directed ortho C-H methylation and d3-methylation of benzoic acids was reported. The method used com. available reagents and precatalyst and requires no inert atm. or exclusion of moisture. Substrates bearing electron-rich and electron-poor groups were successfully methylated, including compounds with competing directing/coordinating groups. The method was also applied to the LSF of several marketed drugs, forming analogs with increased metabolic stability compared with the parent drug. The experimental process involved the reaction of 3-Bromo-2-fluoro-6-methyl-benzoic acid(cas: 1427433-22-4).Application of 1427433-22-4
The Article related to benzoic acid potassium methyltrifluoroborate iridium catalyst regioselective methylation, methylbenzoic acid preparation, applied chemistry, chemistry, green chemistry, organic chemistry and other aspects.Application of 1427433-22-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary