On October 14, 2021, Reynolds, Dominic; Leger, Serge; Seiler, Michael W.; Agrawal, Anant A.; Vaillancourt, Frederic; Smith, Peter; Hopper, Allen T.; Prajapati, Sudeep; Soueidan, Olivier published a patent.SDS of cas: 1196157-51-3 The title of the patent was Preparation of quinazolinone, phthalazinone and isoquinolinone compounds for modulating splicing. And the patent contained the following:
The present disclosure features compounds I [A = (un)substituted cycloalkyl, heterocyclyl, aryl, or heteroaryl; Rb = B, (un)substituted alkyl, or heteroalkyl; B = (un)substituted cycloalkyl, heterocyclyl, aryl, or heteroaryl; Y = N, (un)substituted CH, or CH2; R2 = (independently) H or alkyl; R3 = (halo)alkyl, halo, cyano, etc.; each of L1 and L2 = (independently) absent, alkylene, heteroalkylene, O, etc.; m = 0-3; n = 0-2] or pharmaceutically acceptable salts, and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof. E.g., a multi-steps synthesis of II, starting from 2-methyl-2H-indazole-5-carboxylic acid, was described. Exemplified compounds I were tested for their RNA splicing modulatory activity (data given for representative compounds I). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of 2-Amino-6-bromonicotinic acid(cas: 1196157-51-3).SDS of cas: 1196157-51-3
The Article related to quinazolinone phthalazinone isoquinolinone preparation splicing nucleic acid rna modulator, premrna dna rna spliceosome modulator quinazolinone phthalazinone isoquinolinone preparation and other aspects.SDS of cas: 1196157-51-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary