Halik, Pawel K.; Lipinski, Piotr F. J.; Matalinska, Joanna; Kozminski, Przemyslaw; Misicka, Aleksandra; Gniazdowska, Ewa published an article in 2020, the title of the article was Radiochemical synthesis and evaluation of novel radioconjugates of neurokinin 1 receptor antagonist aprepitant dedicated for NK1R-positive tumors.Recommanded Product: 574-98-1 And the article contains the following content:
Aprepitant, a lipophilic and small mol. representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action. In the presented research, we developed two novel structural modifications of aprepitant to create aprepitant conjugates with different radionuclide chelators. All of them were radiolabeled with 68Ga and 177Lu radionuclides and evaluated in terms of their lipophilicity and stability in human serum. Furthermore, fully stable conjugates were examined in mol. modeling with a human neurokinin 1 receptor structure and in a competitive radioligand binding assay using rat brain homogenates in comparison to the aprepitant mol. This initial research is in the conceptual stage to give potential theranostic-like radiopharmaceutical pairs for the imaging and therapy of neurokinin 1 receptor-overexpressing cancers. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Recommanded Product: 574-98-1
The Article related to aprepitant radiopharmaceutical neurokinin receptor antagonist radionuclide chelator, aprepitant, neurokinin 1 receptor antagonist, radionuclide chelators, radiopharmaceuticals and other aspects.Recommanded Product: 574-98-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary