On January 3, 2013, Geneste, Herve; Ochse, Michael; Drescher, Karla; Behl, Berthold; Laplanche, Loic; Dinges, Juergen; Jakob, Clarissa published a patent.Product Details of 1214362-62-5 The title of the patent was Preparation of isoindole carboxamides, pyrrolopyridine carboxamides, and similar compounds as inhibitors of phosphodiesterase type 10A for treating neurological and psychiatric disorders. And the patent contained the following:
The present invention relates to novel carboxamide compounds of general formula I (wherein X1-X4 are N or (un)substituted CH, with provisos; A is O, S, SO, SO2, substituted N, or (un)substituted CH2; Het is monocyclic hetaryl, fused bicyclic hetaryl, or Ph, all of which may be substituted; and R7-R10 are independently H, halo, C1-4 alkyl, etc.), pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable therapeutic properties as inhibitors of phosphodiesterase type 10A and are particularly suitable for treating or controlling medical disorders selected from neurol. disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders. Synthetic procedures for preparing I are exemplified. Example compound II was prepared in a 5-step synthesis that culminated in reaction of 4-methyl-[2,4′]bipyridinyl-3-carboxylic acid Me ester and 2-quinolin-2-ylethylamine. In a PDE10A inhibition assay, II had an IC50 <100 nM. The experimental process involved the reaction of Ethyl 2-bromo-6-fluorobenzoate(cas: 1214362-62-5).Product Details of 1214362-62-5
The Article related to isoindole pyrrolopyridine carboxamide preparation inhibitor pde10a neurol psychiatric disorder, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Product Details of 1214362-62-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary