On September 30, 2022, Ekinci, Orhan; Akkoc, Mitat; Khan, Siraj; Yasar, Sedat; Guerses, Canbolat; Noma, Samir; Balcioglu, Sevgi; Sen, Betuel; Ayguen, Muhittin; Yilmaz, Ismet published an article.Application In Synthesis of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Synthesis and biological evaluation of Au-NHC complexes. And the article contained the following:
New seven Au-N-heterocyclic carbene (NHC) complexes were synthesized via transmetalation from Ag-NHC complexes. NHC salts, Ag-NHC, and Au-NHC complexes were fully characterized by widely used spectroscopic techniques. The mol. and crystal structures of 3b and 3f Au-NHC complexes were clarified through the single-crystal x-ray diffraction method. According to x-ray diffraction anal. results, the coordination geometry around Au(I) atoms in the complexes are revealed to be almost linear with C-Au-Cl angle. Anticancer activity, DNA binding, xanthine oxidase (XO) inhibitory activity studies, and mol. docking studies were evaluated for all Au-NHC complexes to explore the binding mechanism at the active site. The IC50 value of Au-NHC complexes against human colorectal cancer (Caco-2) and breast cancer (MCF-7) cell lines was defined by MTT assay. The IC50 values for MCF-7 in the range of 5.2 ± 2 to 152.4 ± 1μM and Caco-2 5.2 ± 1 to 152.7 ± 2μM showed that 3a, 3b, 3c, 3d, and 3g have better anticancer activity than Cisplatin incredibly complex 3a against both cancer cell line. All Au-NHC complexes showed excellent antimicrobial activity against different bacteria and fungi. 3a was the complex that exhibited the best antimicrobial activity here as well. The XO inhibitory activity exptl. results indicated that all gold complexes showed remarkable inhibition activity against XO compared to the generally used standard, allopurinol. The range of IC50 value was determined from 0.407 to 2.681μM. 3d complex showed the lowest IC50 value at 0.407μM. DNA binding experiments were performed using agarose gel electrophoresis to observe the ability of synthesized Au-NHC complexes to interact with the supercoiled pUC19 plasmid DNA. Mol. docking studies were performed to determine the binding mode of all active compounds against the XO enzyme, antibacterial, antifungal, and MCF-7 cell lines. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Application In Synthesis of 2-(2-Bromoethyl)isoindoline-1,3-dione
The Article related to silver gold heterocyclic carbene complex halo preparation crystal structure, antitumor human silver gold heterocyclic carbene complex halo, antibacterial antifungal silver gold heterocyclic carbene complex halo dna and other aspects.Application In Synthesis of 2-(2-Bromoethyl)isoindoline-1,3-dione
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary