A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Quality Control of 1575-37-7.
Yan, Liuqing;Fu, Jiaxu;Li, Shuang;Zhang, Jinlong;Wang, Shuang;Gu, Qiang;Zhang, Yumin;Lin, Feng research published 《 Microwave-assisted Synthesis and In vitro Bioactivity Evaluation of Benzimidazoles Bearing Phenolic Hydroxyl》, the research content is summarized as follows. An efficient and facile method was introduced for the synthesis of benzimidazoles in this paper. The optimum reaction conditions were determined A series of benzimidazoles bearing phenolic hydroxyl were synthesized in moderate to excellent yields starting from different substituted hydroxy benzaldehyde and 4-position substituted o-phenylenediamine via nu-cleophilic addition in the presence of catalyst Na2S2O5 under microwave irradiation Herein, effects of the catalyst, molar ratio of reactants, reaction temperature and solvent were investigated. The optimal reaction condition was determined The effect of DMF and EtOH solvent on the reaction was compared. Further, the bacteriostatic activities of the synthesized compounds were evaluated with ciprofloxacin and itraconazole as a pos. control, resp. Few compounds exhibited some antibacterial activity. The lowest MIC of antibacterial activity of compound I was 32μg/mL. Meanwhile, the luminescence property of compound I was studied. The antibacterial activity of compound I, along with their good fluorescence performance highlighted the potential of these compounds as lead structures and owned fluorescence trace for further study towards the development of novel drugs and functional mechanisms in living organisms.
Quality Control of 1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary