Organic compounds having carbon bonded to bromine are called organic bromides. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. COA of Formula: C7H6Br2.
Wu, Tianxiao;Zhang, Chu;Lv, Ruicheng;Qin, Qiaohua;Liu, Nian;Yin, Wenbo;Wang, Ruifeng;Sun, Yin;Wang, Xiaoyan;Sun, Yixiang;Zhao, Dongmei;Cheng, Maosheng research published 《 Design, synthesis, biological evaluation and pharmacophore model analysis of novel tetrahydropyrrolo[3,4-c]pyrazol derivatives as potential TRKs inhibitors》, the research content is summarized as follows. Synthesis, biol. evaluation and pharmacophore model anal. of novel tetrahydropyrrolo[3,4-c]pyrazol derivatives I [Ar1 = Ph, 2-FC6H4, 3-ClC6H4, etc.] and II [R1 = H, F; R2 = H, F; Ar2 = 4-FC6H4, 2-naphthyl, 4-morpholinophenyl, etc.] as potential TRKs inhibitors were obtained using scaffold hopping strategy. Compound II [R1 = H; R2 = F; Ar2 = 4-(4-methylpiperazin-1-yl)-phenyl] significantly inhibited the proliferation of TRK-dependent cell lines (Km-12), while it had no inhibitory effect on TRK-independent cell lines (A549 and THLE-2). Furthermore, kinases selectivity profiling showed that in addition to TRKs, compound II [R1 = H; R2 = F; Ar2 = 4-(4-methylpiperazin-1-yl)-phenyl] only displayed relatively strong inhibitory activity on ALK. These data might indicated that compound II [R1 = H; R2 = F; Ar2 = 4-(4-methylpiperazin-1-yl)-phenyl] had a good drug safety. Partial ADME properties were evaluated in vitro and in vivo and compound II [R1 = H; R2 = F; Ar2 = 4-(4-methylpiperazin-1-yl)-phenyl] exhibited a good AUC values and volume of distribution and low clearance in the pharmacokinetics experiment of rats.
COA of Formula: C7H6Br2, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.
3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.
3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., 823-78-9.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary