Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Reference of 244205-40-1.
Wood, James M.;Satam, Nishikant S.;Almeida, Renata G.;Cristani, Vinicius S.;de Lima, Denis P.;Dantas-Pereira, Luiza;Salomao, Kelly;Menna-Barreto, Rubem F. S.;Namboothiri, Irishi N. N.;Bower, John F.;da Silva, Eufranio N. Junior research published 《 Strategies towards potent trypanocidal drugs: Application of Rh-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi》, the research content is summarized as follows. Rhodium-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulations and nitroalkene reactions were employed for the synthesis of 56 quinone-based compounds such as I [R1 = H, I, OMe, NMePh, etc.; R2 = H, Me, Ph, etc.], II [R = 2-Me, 2-OMe, 4-OEt, etc.] and III [X = O, NBu, NPh, etc.; Ar = Ph, 4-tolyl, 2-furyl, etc.]. These were evaluated against Trypanosoma cruzi, the parasite that causes Chagas disease. The reactions described here were part of a program that aims to utilize modern, versatile and efficient synthetic methods for the one or two step preparation of trypanocidal compounds Among the tested compounds 9 compounds were identified with potent activity against the parasite; 3 of these were 30-fold more potent than benznidazole, a drug used for the treatment of Chagas disease. This article provides a comprehensive outline of reactions involving over 120 compounds aimed at the discovery of new quinone-based frameworks with activity against T. cruzi.
Reference of 244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary