Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Electric Literature of 244205-40-1.
Wang, Min;Liu, Yue;Wang, Liying;Lu, Haifeng;Feng, Lei;Gao, Hongyin research published 《 Cascade Chan-Lam C-O Coupling/[3,3]-Rearrangement of Arylhydroxylamines with Arylboronic Acids Toward NOBIN Analogues》, the research content is summarized as follows. A copper-mediated Chan-Lam type O-arylation of arylhydroxylamines RN(OH)R1 (R = naphthalen-2-yl, Ph, 6-methoxy-5-(naphthalen-1-yl)pyridin-3-yl, etc.;R1 = Bz, BOC, Cbz, etc.) with arylboronic acids R2B(OH)2 (R2 = Ph, phenanthren-9-yl, naphthalen-2-yl, etc.) to generate transient N,O-diarylhydroxylamines e.g., N-(1-(2-hydroxyphenyl)naphthalen-2-yl)benzamide that could rapidly undergo cascade [3,3]-sigmatropic rearrangement and rearomatization to afford NOBIN e.g., (R)-N-(2′-hydroxy-[1,1′-binaphthalen]-2-yl)benzamide and e.g., (S)-2′-benzamido-[1,1′-binaphthalen]-2-yl isobutyrate analogs under mild conditions was developed. The newly synthesized racemic biaryl products e.g., N-(2′-hydroxy-[1,1′-binaphthalen]-2-yl)benzamide can be further resolved by a chiral DMAP-catalyzed O-acylation/kinetic resolution protocol.
Electric Literature of 244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary