Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Recommanded Product: 4-Bromobenzene-1,2-diamine.
Wang, Ao;Wang, Yawan;Meng, Xin;Yang, Yushe research published 《 Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer》, the research content is summarized as follows. Two series of novel thiohydantoin derivatives of enzalutamide I (X = C, N, S; R = Br, Ph, 3-pyridyl) and II (M = C, N; A = di-Me, cyclobutyl, oxetanyl, etc.; X = C, N; Y = O, N-methyl; n = 0, 1) as potent androgen receptor (AR) antagonists were designed and synthesized. Among them, compound II (M = C; A = dimethyl; X = C; Y = O; n =1) was identified as an AR antagonist which was 2.3-fold more potent than enzalutamide. Mol. docking studies were performed to explain the improved potency of II (M = C; A = dimethyl; X = C; Y = O; n =1) at AR. In cell proliferation assays, II (M = C; A = dimethyl; X = C; Y = O; n =1) exhibited similar anti-proliferative activities with enzalutamide against hormone sensitive LNCaP cells and AR-overexpressing LNCaP/AR cells. These data indicated that II (M = C; A = dimethyl; X = C; Y = O; n =1) can be a good lead compound for further structure optimization for the treatment of prostate cancer.
1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Recommanded Product: 4-Bromobenzene-1,2-diamine
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary