Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Related Products of 1575-37-7.
Tran, Duc N.;Zhdanko, Alexander;Barroso, Santiago;Nieste, Patrick;Rahmani, Ramdane;Holan, Jan;Hoefnagels, Roel;Reniers, Peter;Vermoortele, Frederik;Duguid, Stewart;Cazanave, Lionel;Figlus, Marek;Muir, Colin;Elliott, Alain;Zhao, Peichao;Paden, Warren;Diaz, Cristina Hernandez;Bell, Stephen J.;Hashimoto, Akihiro;Phadke, Avinash;Wiles, Jason A.;Vogels, Ilse;Farina, Vittorio research published 《 Development of a Commercial Process for Odalasvir》, the research content is summarized as follows. Odalasvir is a selective inhibitor of hepatitis C virus NS5A protein, a key target for combination therapies. This paper described the chem. process development for the synthesis of this API and the improvements that were achieved over the medicinal chem. Optimization of all the reaction conditions and crystallizations resulted in higher throughput and a highly improved process mass intensity (PMI). The process was robust and it was scaled up to ∼100 kg batches without issues.
1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Related Products of 1575-37-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary