Month: October 2022

Wang, Chengcheng; Wang, Yang; Wang, Guanyang; Huang, Chusen; Jia, Nengqin published the artcile< A new mitochondria-targeting fluorescent probe for ratiometric detection of H2O2 in live cells>, Category: bromides-buliding-blocks, the main research area is mitochondria fluorescent probe hydrogen peroxide live cell; Hydrogen peroxide; Live cell imaging; Mitochondria; Quantitative detection; Ratiometric fluorescent probe.

With this research the authors presented a ratiometric and mitochondria-target fluorescent probe (Mito-HT) (I) for detection of H2O2 both in vitro and in live cells. Mito-HT was constructed by direct conjugation of aryl boronate to fluorophore with three synthetic steps. The borate group is cleaved from Mito-HT in the presence of H2O2, resulting in the exposure of the hydroxyl group of the electron donating group. Then the ICT mechanism was turned on, and the fluorescence emission of Mito-HT at 493 nm was red shifted to 562 nm, thereby achieving radiometric detection of H2O2. Mito-HT exhibited a highly selectivity towards H2O2, and this interaction can be completed within 40 min. Mito-HT could be used for quant. detection of H2O2 (0-200μM) through ratiometric fluorescence signal readout. And limit of detection (LOD) is ∼0.33μM. The relatively high stability and medium fluorescence quantum yield of Mito-HT (0.39) and Mito-HT-OH (0.43) enable clear mitochondria localization and dual-channel fluorescence imaging of H2O2 in live cells with confocal microscopy.

Analytica Chimica Acta published new progress about Fluorescence imaging. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jeffs, P. W.; Hansen, J. F.; Brine, G. A. published the artcile< Photochemical synthesis of 6,7-dihydro-5H-dibenz[c,e]azepine and 5,6,7,8-tetrahydrodibenz[c,e]azocine derivatives>, Synthetic Route of 17100-65-1, the main research area is dibenzoxepine; dibenzazepine; dibenzazocine; cyclization iododibenzylamine; photolysis iododibenzylamine; benzylamine iodo cyclization; iododibenzylamine cyclization; conformation dibenzazocine.

Photolysis of several substituted 2-iododibenzylamine hydrochlorides in aqueous solution provided convenient syntheses of the corresponding 6,7-dihydro-5H-dibenz[c,e]azepines in useful yields. Thus, irradiation of o-IC6H4CH2NHCH2Pb gave 57% dibenzazepine I. Irradiation of o-IC6H4CH2NHCH2C6H3(OMe)2-3.5 yielded only 2,4,6-(MeO)2CHOCH2)C6H2C6H4CH2OH-o together with a small amount of dibenzoxepine II. Photolysis of three N-(2-halogenobenzyl)-β-phenethylamine hydrochlorides provided convenient syntheses of the corresponding 5,6,7,8-tetrahydrodibenz[c,e]azocines. Thus, irradiation of O-IC6H4CH2NHCH2CH2Pb gave 33% dibenzazocine III. NMR examination of the dibenzazocines confirmed that they existed in a skewed biphenyl conformation, and that inversion of the system by rotation through the planar biphenyl was hindered.

Journal of Organic Chemistry published new progress about Cyclization. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Synthetic Route of 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Majumder, Adhir; Naskar, Rajat; Phukan, Shankab J.; Maity, Ramananda published the artcile< Bimetallic PdII complexes with NHC/Py/PCy3 donor set ligands: applications in α-arylation, Suzuki-Miyaura and Sonogashira coupling reactions>, Quality Control of 576-83-0, the main research area is palladium binuclear imidazolylidene pyridine tricyclohexylphosphine complex preparation catalyst; Suzuki Sonogashira coupling catalyst palladium binuclear imidazolylidene tricyclohexylphosphine complex; alpha arylation oxindole catalyst palladium binuclear imidazolylidene tricyclohexylphosphine complex; crystal mol structure palladium binuclear imidazolylidene pyridine tricyclohexylphosphine complex.

Palladium binuclear NHC-pyridine and NHC-tricyclohexylphosphine complexes Me2C6H2-1,4-(MeImPdI2L)2 (2-5; MeIm = 3-methyl-1-imidazolyl-2-ylidene; L = 3-ClPy, 4-ClPy, 4-MeOPy, PCy3) were prepared and evaluated as catalysts for α-arylation of oxindole, Sonogashira coupling of PhCCH and Suzuki coupling of 3-bromo- and 4-bromobenzaldehyde with arylboronic acids. Bimetallic complexes bearing NHC donor ligands are gaining immense popularity as catalysts in organometallic chem. However, such complexes with a mixed NHC/PR3 donor set ligands are still rare. We present here a series of bimetallic PdII complexes featuring mixed NHC/Py/PCy3 donor set ligands applied in α-arylation of amide, Suzuki-Miyaura coupling and Sonogashira coupling reactions. All complexes have been characterized using standard characterization techniques and one of the complexes has been structurally characterized by X-ray crystallog. anal. Catalytic outcomes clearly indicate the superior activity of PdII complex bearing mixed NHC/PCy3 donor set ligands compared to the PEPPSI-type complexes in both α-arylation of amide and Sonogashira coupling reactions, though almost similar activities were observed for all the complexes in Suzuki-Miyaura coupling reactions. This observation might be due to the involvement of Pd-NPs as an active catalyst in Suzuki-Miyaura coupling reactions, whereas the Hg-poison test suggested the homogeneous nature of the other two types of reactions. Two pyridine rings in a mixed NHC/4-OMe(Py) donor complex are oriented almost in a parallel face-to-face fashion with a centroid to centroid separation of 3.758 Å, indicating π···π interactions between two methoxypyridine rings. This interaction leads to a very short Pd···Pd distance of 5.754 Å in the aforementioned complex.

New Journal of Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Quality Control of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Linstad, Ethan J.; Vavere, Amy L.; Hu, Bao; Kempinger, Jayson J.; Snyder, Scott E.; DiMagno, Stephen G. published the artcile< Thermolysis and radiofluorination of diaryliodonium salts derived from anilines>, Synthetic Route of 639520-70-0, the main research area is aniline diaryliodonium salt preparation radiofluorination.

Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in relatively complex mols., such as flutemetamol.

Organic & Biomolecular Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Synthetic Route of 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary