Month: October 2022

Jiang, Wen-Nian; Zhao, Qing-Lan; Cheng, Wen-Shuo; Xiao, Jun-An; Xiang, Hao-Yue; Chen, Kai; Yang, Hua published the artcile< CuI-mediated benzannulation of (ortho-arylethynyl)phenylenaminones to assemble α-aminonaphthalene derivatives>, Recommanded Product: 4-Bromobenzylamine, the main research area is aminonaphthalene preparation; arylethynyl phenylenaminone amine preparation benzannulation copper iodide catalyst.

Simple manipulation of exogenous amines readily offers the structural diversity of the resulting α-aminonaphthalenes II. Preliminary investigation of the photophys. features of the representative as-prepared compounds demonstrated their tunable fluorescence properties. A copper-mediated annulation protocol for new (ortho-arylethynyl)phenyl enaminones I (R = dimethylaminyl, pyrrolidin-1-yl, cyclohexylaminyl, etc.; R1 = H, 4-(C(O)2CH3)C6H4, 4-NCC6H4; R2 = C6H5, 4-(CH2CH3)C6H4, 4-((CH2)2CH3)C6H4, 4-((CH2)3CH3)C6H4, 4-CH3OC6H4, 4-FC6H4) bearing a N,N-dimethylamine moiety was developed to facilely install a series of α-aminonaphthalene derivatives II.

Organic Chemistry Frontiers published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Peng; Meng, Ling-Hu; Chen, Lang; Guo, Jun-Kang; Shen, Sheng; Au, Chak-Tong; Yin, Shuang-Feng published the artcile< Double-Shell and Flower-Like ZnS-C3N4 Derived from in Situ Supramolecular Self-Assembly for Selective Aerobic Oxidation of Amines to Imines>, Electric Literature of 3959-07-7, the main research area is Double Shell nanoflower zinc sulfide carbon nitride photocatalyst; photooxidation amines imines.

Multishelled micro-/nanostructures have attracted much research attention because of their unique properties. It is a big challenge to fabricate multishelled hollow structures of complex nanoarchitectures with the resp. shells different in composition Herein, the double-shell and flower-like ZnS-C3N4 (2-ZSCN) was fabricated by a facile supramol. self-assembly method. Because of its unique structure, 2-ZSCN exhibits enhanced photocatalytic activity and stability in the selective aerobic oxidation of amines to imines under visible-light irradiation

ACS Sustainable Chemistry & Engineering published new progress about Aralkyl amines Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Electric Literature of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wilson, Katy B.; Nedzbala, Hannah S.; Simpson, Spenser R.; Ericson, Megan N.; Westendorff, Karl S.; Chordia, Mahendra D.; Dickie, Diane A.; Harman, W. Dean published the artcile< Hydroamination of Dihapto-Coordinated Benzene and Diene Complexes of Tungsten: Fundamental Studies and the Synthesis of γ-Lycorane>, Recommanded Product: 4-Bromobenzylamine, the main research area is hydroamination dihapto benzene diene tungsten complex; gamma lycorane preparation; crystal mol structure dihapto alkene tungsten complex; arenes; cyclohexenes; dearomatization; dienes; hydroamination; lycorane; nitrosyl ligands; tungsten.

Reactions are described for complexes of the form WTp(NO)(PMe3)(η2-arene) and various amines, where the arene is benzene or benzene with an electron-withdrawing substituent (CF3, SO2Ph, SO2Me). The arene complex is first protonated to form an η2-arenium species, which then selectively adds the amine. The resulting η2-5-amino-1,3-cyclohexadiene complexes can then be subjected to the same sequence with a second nucleophile to form 3-aminocyclohexene complexes, where up to three stereocenters originate from the arene carbons. Alternatively, 1,3-cyclohexadiene complexes containing an ester group at the 5 position (also prepared from an arene) can be treated with acid followed by an amine to form trisubstituted 3-aminocyclohexenes. When the amine is primary, ring closure can occur to form a cis-fused bicyclic γ-lactam. Highly functionalized cyclohexenes can be liberated from the tungsten through oxidative decomplexation. The potential utility of this methodol. is demonstrated in the synthesis of the alkaloid γ-lycorane. An enantioenriched synthesis of a lactam precursor to γ-lycorane is also described. This compound is prepared from an enantioenriched version of the tungsten benzene complex. Regio- and stereochem. assignments for the reported compounds are supported by detailed 2D-NMR anal. and 13 mol. structure determinations (SC-XRD).

Helvetica Chimica Acta published new progress about Crystal structure. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Wei-Li; Li, Kun; Liao, Wei-Cong; Liang, Wang-Fu; Qiu, Pei-Wen; Liang, Cui; Su, Gui-Fa; Mo, Dong-Liang published the artcile< An iron(III)-catalyzed dehydrogenative cross-coupling reaction of indoles with benzylamines to prepare 3-aminoindole derivatives>, Category: bromides-buliding-blocks, the main research area is amino indole derivative green preparation diastereoselective; indole benzylamine dehydrogenative cross coupling iron catalyst.

A green cascade approach to prepare a variety of 3-aminoindole derivatives I [R1 = H, 7-Me, 6-Cl, etc.; R2 = H, Me; R3 = Ph, 3-BrC6H4, 2-naphthyl, etc.; R4 = Ph, 2-FC6H4, 3-pyridyl, etc.; R5 = H, Et, Ph] in good to excellent yields through an iron(III)-catalyzed dehydrogenative cross-coupling reaction of 2-arylindoles and primary benzylamines under mild reaction conditions was reported. The reaction showed a broad substrate scope of indoles and benzylamines and tolerated a wide range of functional groups. Moreover, the reaction was easily performed at the gram scale without producing waste after the reaction was completed. The present method highlighted readily available starting materials, a simple purification procedure and the usage of cheap, nontoxic and environmentally benign iron(III) catalyst.

Green Chemistry published new progress about Aromatic amines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Canh Pham, Em; Truong, Tuyen Ngoc published the artcile< Design, Microwave-Assisted Synthesis, Antimicrobial and Anticancer Evaluation, and In Silico Studies of Some 2-Naphthamide Derivatives as DHFR and VEGFR-2 Inhibitors>, SDS of cas: 3959-07-7, the main research area is naphthamide preparation microwave antibacterial antifungal anticancer DHFR VEGFR inhibitor.

Naphthamide is a common structural framework with diverse pharmacol. activities. Ten novel 2-naphthamide derivatives I (R = 3-(morpholin-4-yl)propyl, (4-methylphenyl)methyl, (4-methoxyphenyl)methyl, (4-bromophenyl)methyl, (4-chlorophenyl)methyl; R1 = H, OMe; R2 = H, OMe; R3 = H, OMe; R4 = H, OMe) have been designed, synthesized, and evaluated for their in vitro antibacterial, antifungal, and anticancer activities. The title compounds were synthesized from dimethoxybenzaldehyde derivatives such as 2,4-dimethoxybenzaldehyde and 3,5-dimethoxybenzaldehyde through a four-step microwave-assisted synthesis process. The structures were confirmed by 1H NMR, 13C NMR, and MS spectra. Compound I [R = (4-chlorophenyl)methyl ; R1 = R3 = H; R2 = R4 = OMe] (II) showed good antibacterial activity against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA, and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, resp., compared to ciprofloxacin (MIC = 8-16 μg/mL). Compounds I (R = (4-methylphenyl)methyl ; R1 = R3 = H; R2 = R4 = OMe)(III) (IC50 = 3.59-8.38 μM) and II (IC50 = 2.97-7.12 μM) exhibited good cytotoxic activity against C26, HepG2, and MCF7 cancer cell lines as compared to paclitaxel (IC50 = 2.85-5.75 μM). Moreover, compounds II and III exhibited better anticancer activity than PTX against the C26 cell line. In particular, compound II showed potent in vitro VEGFR-2 inhibitory activity with the IC50 value of 0.384 μM compared with sorafenib (IC50 = 0.069 μM). Therefore, compound II is the most potent compound for anticancer activity as indicated by in vitro cell line inhibition, in silico ADMET, mol. docking, and in vitro VEGFR-2 inhibition studies.

ACS Omega published new progress about Absorption. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary