Month: October 2022

Li, Xuejing; Deng, Xingwang; Coyne, Anthony G.; Srinivasan, Rajavel published the artcile< meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C-H Borylation>, Application of C8H9Br, the main research area is meta nitroarene regioselective preparation; arene borylation nitration tandem iridium catalyst copper; C−H borylation; copper catalysis; nitration; nitro(hetero)arenes; one-pot reactions.

The meta-nitration of arenes bearing ortho/para directing group(s) using the iridium-catalyzed C-H borylation reaction followed by a newly developed copper(II)-catalyzed transformation of the crude aryl pinacol boronate esters into the corresponding nitroarenes RNO2 [R = 4,5-di-ClC6H3, 3,4-di-BrC6H3, 5-Cl-3-pyridyl, etc.] in a one-pot fashion was reported. The reaction tolerated a wide array of ortho/para-directing groups, such as -F, -Cl, -Br, -CH3, -Et, -iPr -OCH3 and -OCF3. It also provided regioselective access to the nitro derivatives of π-electron-deficient heterocycles, such as pyridine and quinoline derivatives The application of this method was demonstrated in the late-stage modification of complex mols. and also in the gram-scale preparation of an intermediate en route to the FDA-approved drug Nilotinib. Finally, showed that the nitro product obtained by this strategy could also be directly converted to the aniline or hindered amine through Baran’s amination protocol.

Chemistry – A European Journal published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Application of C8H9Br.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Marvi, Omid; Giahi, Masoud published the artcile< Montmorillonite KSF clay as novel and recyclable heterogeneous catalyst for the microwave mediated synthesis of indan-1,3-diones>, Related Products of 82-73-5, the main research area is montmorillonite clay catalyst microwave irradiation indan dione synthesis.

Various indan-1,3-dione derivatives were synthesized from the reaction of different phthalic anhydrides with diethyl-malonate using montmorillonite KSF clay as a recyclable heterogeneous acidic catalyst and microwave irradiation in good yields and short reaction times.

Bulletin of the Korean Chemical Society published new progress about Microwave irradiation. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Related Products of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gao, Hang; Zhang, Nan; Li, Yang; Zhao, Wei; Quan, Yiwu; Cheng, Yixiang; Chen, Hong-Yuan; Xu, Jing-Juan published the artcile< Trace Ir(III) complex enhanced electrochemiluminescence of AIE-active Pdots in aqueous media>, Recommanded Product: 1,2-Bis(4-bromophenyl)-1,2-diphenylethene, the main research area is polytetraphenylethene iridium complex Suzuki coupling polymerization electrochemiluminescence.

Trace Ir(III) complex enhanced aggregation-induced electrochemiluminescence (AIECL) of poly-tetraphenylethene (pTPE) in aqueous media was investigated for the first time. The poly-TPE end-capped by Ir(III) complex (Ir@pTPE) and its corresponding model polymer poly-TPE (Ph@pTPE) could be synthesized by Suzuki coupling polymerization reaction of 1,2-bis(4-bromophenyl)- 1,2-diphenylethene (M-1) with 1,2-diphenyl-1,2-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethene (M-2) and the continuous Suzuki coupling end-capped reaction of poly-TPE-pinacol boronate with (pq)2Ir(pico)Br and bromobenzene, resp. Subsequently, the corresponding Ir@pTPE Pdots and Ph@pTPE Pdots encapsulated with poly(styrene- co-maleicanhydride) (PSMA) could be obtained by nano-precipitation method. Compared with Ph@pTPE Pdots, the Ir@pTPE Pdots with a trace amount of Ir(III) complex (1.34‰ of Ir(III) content, wt) could exhibit 9.9-fold enhancement of the electrochemiluminescence (ECL) signal for visual emission. This work provided a novel strategy on designing highly efficient ECL materials based on trace Ir(III)-end capping AIE-active polymer dots. electrochemiluminescence, aggregation-induced emission, Ir(III) complex, polymer dots.

Science China: Chemistry published new progress about Electric current-potential relationship. 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, Recommanded Product: 1,2-Bis(4-bromophenyl)-1,2-diphenylethene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yamano, Ryota; Hara, Jun; Murayama, Koichi; Sugiyama, Haruki; Teraoka, Kota; Uekusa, Hidehiro; Kawauchi, Susumu; Shibata, Yu; Tanaka, Ken published the artcile< Rh-Mediated Enantioselective Synthesis, Crystal Structures, and Photophysical/Chiroptical Properties of Phenanthrenol-Based [9]Helicene-like Molecules>, Application of C7H7BrO2, the main research area is enantioselective synthesis phenanthrenol based nonahelicene.

The enantioselective synthesis of phenanthrenol-based [9]helicene-like mols. has been achieved via the rhodium-mediated intramol. [2+2+2] cycloadditions of 3-phenanthrenol-linked triynes. Crystal structures and photophys./chiroptical properties of these [9]helicene-like mols. were compared with the corresponding [7]helicene-like mols.

Organic Letters published new progress about [2+2+2] Cycloaddition reaction. 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Application of C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Patel, Harun; Chaudhari, Kavita; Jain, Pritam; Surana, Sanjay published the artcile< Synthesis and in vitro antitubercular activity of pyridine analouges against the resistant Mycobacterium tuberculosis>, Application In Synthesis of 82-73-5, the main research area is pyridinyl hydrazide preparation antitubercular activity SAR; Schiff base pyridinyl preparation antitubercular activity SAR; Cytotoxicity; MDR-MTB; Mycobacterium tuberculosis; Synthesis.

Synthesis and the biol. activity of isoniazid and pyridine derivatives were successfully carried out with elaborated characterization by spectral data. Amongst the synthesized compounds; I and II displayed encouraging antimycobacterial activity with IC50 of 3.2μM and 1.5μM against the H37Rv strain. The MIC of test compounds I and II were also assessed against the 5 drug resistant isolates (FQ-R1, INH-R1, INH-R2, RIF-R1 and RIF-R2) of MTB strains under aerobic conditions and compound I [MIC = 3.2μM for FQ-R1; MIC = 140μM for INH-R1; MIC = 160μM for INH-R2; MIC = 2.4μM towards RIF-R1; MIC = 4.2μM for RIF-R2] and II [MIC = 3.3μM for FQ-R1; MIC = 170μM for INH-R1; MIC = 190μM for INH-R2; MIC = 1.8μM for RIF-R1; MIC = 8.4μM for RIF-R2] have shown significant activity at non-cytotoxic concentration in comparison to the standard drug.

Bioorganic Chemistry published new progress about Drug toxicity. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Application In Synthesis of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vishnumurthy, Kodumuru; Makriyannis, Alexandros published the artcile< Novel and efficient one-step parallel synthesis of dibenzopyranones via Suzuki-Miyaura cross coupling>, Reference of 6942-39-8, the main research area is dibenzopyranone preparation; bromoarylcarboxylate hydroxyarylboronic acid Suzuki Miyaura coupling lactonization.

Microwave-promoted novel and efficient one-step parallel synthesis of dibenzopyranones and heterocyclic analogs from bromo arylcarboxylates and o-hydroxyarylboronic acids via Suzuki-Miyaura cross coupling reaction is described. Spontaneous lactonization gave dibenzopyranones and heterocyclic analogs bearing electron-donating and -withdrawing groups on both aromatic rings in good to excellent yields.

Journal of Combinatorial Chemistry published new progress about Aromatic carboxylic acids, salts Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Reference of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary