A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Quality Control of 70-23-5.
Sigalapalli, Dilep Kumar;Kiranmai, Gaddam;Parimala Devi, G.;Tokala, Ramya;Sana, Sravani;Tripura, Chaturvedula;Jadhav, Govinda Shivaji;Kadagathur, Manasa;Shankaraiah, Nagula;Nagesh, Narayana;Babu, Bathini Nagendra;Tangellamudi, Neelima D. research published 《 Synthesis and biological evaluation of novel imidazo[1,2-a]pyridine-oxadiazole hybrids as anti-proliferative agents: study of microtubule polymerization inhibition and DNA binding》, the research content is summarized as follows. Towards the development of potential anticancer agents, a new series of imidazo[1,2-a]pyridine-oxadiazole hybrids I [R1 = H, Me, R2 = H; R1 = Br, R2 = Me; R3 = Ph, 4-Me2NC6H4, 3,4,5-(MeO)3C6H2, etc.] was synthesized and evaluated for their in vitro anticancer activity against lung cancer (A549) and prostate cancer (PC-3, DU-145) cell lines. Amongst the compounds tested, the compound I [R1 = R2 = H; R3 = 3,4,5-(MeO)2C6H2; (II)] showed the highest potency on A549 cells with an IC50 value of 2.8 ± 0.02μM. Flow cytometric anal. of A549 cells, treated with the compound II, showed apoptosis induction by annexin-v/PI dual staining assay and the effect of II on different phases of cell cycle was also analyzed. Target based studies demonstrated the inhibition of tubulin polymerization by the compound II at an IC50 value of 3.45 ± 0.51μM and its effective binding with CT-DNA. Further, the mol. modeling studies revealed that II has a prominent binding affinity towards α/β-tubulin receptor with admirable physico-chem. properties.
Quality Control of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.
Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.
Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary