One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene, HPLC of Formula: 823-78-9
Siddiqui, Hina;Baheej, M. A. A.;Ullah, Saeed;Rizvi, Fazila;Iqbal, Shazia;Haniffa, Haroon M.;Wahab, Atia-tul;Choudhary, M. Iqbal research published 《 Synthesis of 1,2,3-triazole modified analogues of hydrochlorothiazide via click chemistry approach and in-vitro α-glucosidase enzyme inhibition studies》, the research content is summarized as follows. The current study was aimed to discover potent inhibitors of α-glucosidase enzyme. A 25 membered library of new 1,2,3-triazole derivatives of hydrochlorothiazide (HCTZ, a diuretic drug also being used for the treatment of high blood pressure) was synthesized through click chem. approach. All the synthesized compounds were evaluated for α-glucosidase enzyme inhibition activity. Among them, 18 compounds showed potent inhibitory activity against α-glucosidase with IC50 values between 24 and 379μM. α-Glucosidase inhibitor drug acarbose (IC50 = 875.75 ± 2.08μM) was used as the standard Kinetics studies of few compounds revealed that only compound 6-Chloro-2-((1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide as a mixed-type of inhibitor, while others were non-competitive inhibitors of α-glucosidase enzyme. All the compounds were found to be non-cytotoxic when checked against mouse fibroblast 3T3 cell line.
HPLC of Formula: 823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.
3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.
3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., 823-78-9.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary