Shamsi, Farheen team published research in Bioorganic Chemistry in 2020 | 70-23-5

Reference of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, Reference of 70-23-5

Shamsi, Farheen;Hasan, Phool;Queen, Aarfa;Hussain, Afzal;Khan, Parvez;Zeya, Bushra;King, Hannah M.;Rana, Sandeep;Garrison, Jered;Alajmi, Mohamed F.;Rizvi, M. Moshahid Alam;Zahid, Muhammad;Imtaiyaz Hassan, Md.;Abid, Mohammad research published 《 Synthesis and SAR studies of novel 1,2,4-oxadiazole-sulfonamide based compounds as potential anticancer agents for colorectal cancer therapy》, the research content is summarized as follows. A diverse series of 1,2,4-oxadiazoles, e.g., I was designed, synthesized and evaluated as anticancer agents targeting carbonic anhydrase IX (CAIX). Initial structure-activity anal. suggested that the thiazole/thiophene-sulfonamide conjugates of 1,2,4-oxadiazoles exhibited potent anticancer activities with low μM potencies. 4-Methyl-N-(2-(3-phenyl-1,2,4-oxadiazol-5-yl)thiophen-3yl)benzenesulfonamide exhibited antiproliferative activity (IC50 = 11.1μM) along with appreciable inhibition potential for tumor-associated CAIX (IC50 = 4.23μM) isoform. Therefore, it was structurally optimized and its SAR oriented derivatives II [R1 = Me, Ph, 4-FC6H4, etc.; R2 = Me, Ph] were synthesized and evaluated. This iteration resulted in compound II [R1 = 4-H2NC6H4, R2 = Ph] with an almost two-fold increase in antiproliferative effect (IC50 = 6.0μM) comparable to the clin. drug doxorubicin and significantly higher potency against CAIX (IC50 = 0.74μM). Addnl., compound II [R1 = 4-H2NC6H4, R2 = Ph] treatment decreased the expression of CAIX, induced apoptosis and ROS production, inhibited colony formation and migration of colon cancer cells.

Reference of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary