One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide, Computed Properties of 2576-47-8
Schreib, Benedikt S.;Son, Mina;Aouane, Francoise A.;Baik, Mu-Hyun;Carreira, Erick M. research published 《 Allene C(sp2)-H Activation and Alkenylation Catalyzed by Palladium》, the research content is summarized as follows. Herein, a Pd-catalyzed C-H alkenylation of electronically unbiased allenes e.g., N-(6-(triisopropylsilyl)hepta-4,5-dien-1-yl)picolinamide, affording penta-1,2,4-triene products e.g., I in up to 94% yield was reported. A picolinamide directing group enables the formation of putative allenyl-palladacycles, which subsequently participate in a turnover limiting Heck-type reaction with electron-deficient alkene RCH=CH2 (R = methoxycarbonyl, (benzyloxy)carbonyl, [(4-methyl-2-oxo-2H-chromen-7-yl)oxy]carbonyl, etc.) coupling partners. This mechanistic proposal is consistent with exptl. and computational investigations. Addnl., for the first time, the use of picolinamide N,O-acetals as readily removable auxiliaries for C-H activation reactions, allowing the efficient alkenylation of allenyl carbinol derivatives was reported. Successful removal of the directing groups without affecting the reactive penta-1,2,4-triene substructure of the products e.g., I was demonstrated.
Computed Properties of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary