Organic compounds having carbon bonded to bromine are called organic bromides. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Related Products of 402-49-3.
Reutershan, Michael H.;Machacek, Michelle R.;Altman, Michael D.;Bogen, Stephane;Cai, Mingmei;Cammarano, Carolyn;Chen, Dapeng;Christopher, Matthew;Cryan, John;Daublain, Pierre;Fradera, Xavier;Geda, Prasanthi;Goldenblatt, Peter;Hill, Armetta D.;Kemper, Raymond A.;Kutilek, Victoria;Li, Chaomin;Martinez, Michelle;McCoy, Mark;Nair, Latha;Pan, Weidong;Thompson, Christopher F.;Scapin, Giovanna;Shizuka, Manami;Spatz, Marianne L.;Steinhuebel, Dietrich;Sun, Binyuan;Voss, Matthew E.;Wang, Xiao;Yang, Liping;Yeh, Tammie C.;Dussault, Isabelle;Marshall, C. Gary;Trotter, B. Wesley research published 《 Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction》, the research content is summarized as follows. Identification of low-dose, low-mol.-weight, drug-like inhibitors of protein-protein interactions (PPIs) is a challenging area of research. Despite the challenges, the therapeutic potential of PPI inhibition has driven significant efforts toward this goal. Adding to recent success in this area, we describe herein our efforts to optimize a novel purine carboxylic acid-derived inhibitor of the HDM2-p53 PPI into a series of low-projected dose inhibitors with overall favorable pharmacokinetic and phys. properties. Ultimately, a strategy focused on leveraging known binding hot spots coupled with biostructural information to guide the design of conformationally constrained analogs and a focus on efficiency metrics led to the discovery of MK-4688 (compound 56), a highly potent, selective, and low-mol.-weight inhibitor suitable for clin. investigation.
Related Products of 402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary