Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Organic compounds having carbon bonded to bromine are called organic bromides. Application In Synthesis of 244205-40-1.
Mkrtchyan, Satenik;Jakubczyk, Michal;Lanka, Suneel;Pittelkow, Michael;Iaroshenko, Viktor O. research published 《 Cu-catalyzed arylation of bromo-difluoro-acetamides by aryl boronic acids, aryl trialkoxysilanes and dimethyl-aryl-sulfonium salts: new entries to aromatic amides》, the research content is summarized as follows. A mechanism-guided discovery of a synthetic methodol. that enables the preparation of aromatic amides N-phenethyl-1-naphthamide, 3-chloro-N-cyclopropylbenzamide, N,N-dibenzyl-4-fluorobenzamide, etc. from 2-bromo-2,2-difluoroacetamides 2-bromo-2,2-difluoro-N-(2-phenylethyl)acetamide (I), 2-bromo-N-cyclopropyl-2,2-difluoroacetamide (II), N,N-dibenzyl-2-bromo-2,2-difluoroacetamide (III), etc. utilizing a copper-catalyzed direct arylation was described. Readily available and structurally simple aryl precursors such as aryl boronic acids e.g., naphthalen-1-ylboronic acid, aryl trialkoxysilanes e.g., (3-chlorophenyl)trimethoxysilane and dimethyl-aryl-sulfonium salts e.g., (4-fluorophenyl)dimethylsulfanium trifluoromethanesulfonate were used as the source for the aryl substituents. The scope of the reactions was tested, and the reactions were insensitive to the electronic nature of the aryl groups, as both electron-rich and electron-deficient aryls were successfully introduced. A wide range of 2-bromo-2,2-difluoroacetamides as either aliphatic or aromatic secondary or tertiary amides (e.g., I, II, III) was also reactive under the developed conditions. The described synthetic protocols displayed excellent efficiency and were successfully utilized for the expeditious preparation of diverse aromatic amides in good-to-excellent yields. The reactions were scaled up to gram quantities.
244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., Application In Synthesis of 244205-40-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary