A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Name: 4-Bromobenzene-1,2-diamine.
Malasala, Satyaveni;Ahmad, Naiyaz Md;Akunuri, Ravikumar;Shukla, Manjulika;Kaul, Grace;Dasgupta, Arunava;Madhavi, Y. V.;Chopra, Sidharth;Nanduri, Srinivas research published 《 Synthesis and evaluation of new quinazoline-benzimidazole hybrids as potent anti-microbial agents against multidrug resistant Staphylococcus aureus and Mycobacterium tuberculosis》, the research content is summarized as follows. In the current study, fifteen new Quinazoline-benzimidazole hybrids I (R = H, 4-nitro, 4-chloro, 4-fluoro, 4-bromo; R1 = Ph, 3,4-dimethoxyphenyl, 4-chlorophenyl), II (R2 = trifluoromethyl, 4-bromo-2-florophenyl, 8-chloroquinolin-3-yl, naphthalen-2-yl) and III were designed, synthesized, and evaluated for their antimicrobial activity against S. aureus ATCC 29213 and M. tuberculosis H37Rv. These studies led to the identification of nine compounds potent antibacterial agents I (R = 4-nitro, R1 = Ph; R = 4-chloro, R1 = Ph; R = H, R1 = Ph; R = 4-fluoro, R1 = Ph; R = 4-nitro, R1 = 3,4-dimethoxyphenyl; R = 4-chloro, R1 = 3,4-dimethoxyphenyl; R = H, R1 = 4-chlorophenyl; R = 4-fluoro, R1 = 4-chlorophenyl) and II (R2 = 8-chloroquinolin-3-yl) with MICs in the range of 4-64μg/mL. Further, these selected compounds were found to possess potent antibacterial potential against a panel of drug-resistant clin. isolates which include methicillin and vancomycin-resistant S. aureus. The selected compounds were found to be less toxic to Vero cells (CC50 = 40-≥200μg/mL) and demonstrated a favorable selectivity index. Based on the encouraging results obtained these new benzimidazol-2-yl quinazoline derivatives I have emerged as promising antimicrobial agents for the treatment of MDR- S. aureus and Mycobacterial infections.
Name: 4-Bromobenzene-1,2-diamine, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary