Liu, Longbin team published research in Journal of Medicinal Chemistry in 2021 | 70-23-5

Reference of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 70-23-5, formula is C5H7BrO3, The most pervasive is the naturally produced bromomethane. Reference of 70-23-5

Liu, Longbin;Johnson, Peter D.;Prime, Michael E.;Khetarpal, Vinod;Lee, Matthew R.;Brown, Christopher J.;Chen, Xuemei;Clark-Frew, Daniel;Coe, Samuel;Conlon, Mike;Davis, Randall;Ensor, Samantha;Esposito, Simone;Moren, Anton Forsberg;Gai, Xinjie;Green, Samantha;Greenaway, Catherine;Haber, James;Halldin, Christer;Hayes, Sarah;Herbst, Todd;Herrmann, Frank;Hessmann, Manuela;Hsai, Ming Min;Kotey, Adrian;Mangette, John E.;Mills, Matthew R.;Monteagudo, Edith;Nag, Sangram;Nibbio, Martina;Orsatti, Laura;Schaertl, Sabine;Scheich, Christoph;Sproston, Joanne;Stepanov, Vladimir;Varnas, Katarina;Varrone, Andrea;Wityak, John;Mrzljak, Ladislav;Munoz-Sanjuan, Ignacio;Bard, Jonathan A.;Dominguez, Celia research published 《 [11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins》, the research content is summarized as follows. The expanded polyglutamine-containing mutant huntingtin (mHTT) protein is implicated in neuronal degeneration of medium spiny neurons in Huntington′s disease (HD) for which multiple therapeutic approaches are currently being evaluated to eliminate or reduce mHTT. Development of effective and orthogonal biomarkers will ensure accurate assessment of the safety and efficacy of pharmacol. interventions. We have identified and optimized a class of ligands that bind to oligomerized/aggregated mHTT, which is a hallmark in the HD postmortem brain. These ligands are potentially useful imaging biomarkers for HD therapeutic development in both preclin. and clin. settings. We describe here the optimization of the benzo[4,5]imidazo[1,2-a]pyrimidine series that show selective binding to mHTT aggregates over Aβ- and/or tau-aggregates associated with Alzheimer′s disease pathol. Compound [11C]-2 was selected as a clin. candidate based on its high free fraction in the brain, specific binding in the HD mouse model, and rapid brain uptake/washout in nonhuman primate positron emission tomog. imaging studies.

Reference of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary