Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.
Kung, Pei-Pei;Bingham, Patrick;Burke, Benjamin J.;Chen, Qiuxia;Cheng, Xuemin;Deng, Ya-Li;Dou, Dengfeng;Feng, Junli;Gallego, Gary M.;Gehring, Michael R.;Grant, Stephan K.;Greasley, Samantha;Harris, Anthony R.;Maegley, Karen A.;Meier, Jordan;Meng, Xiaoyun;Montano, Jose L.;Morgan, Barry A.;Naughton, Brigitte S.;Palde, Prakash B.;Paul, Thomas A.;Richardson, Paul;Sakata, Sylvie;Shaginian, Alex;Sonnenburg, William K.;Subramanyam, Chakrapani;Timofeevski, Sergei;Wan, Jinqiao;Yan, Wen;Stewart, Albert E. research published 《 Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library》, the research content is summarized as follows. Two novel compounds were identified as Naa50 binders/inhibitors using DNA-encoded technol. screening. Biophys. and biochem. data as well as cocrystal structures were obtained for both compounds (3a and 4a) to understand their mechanism of action. These data were also used to rationalize the binding affinity differences observed between the two compounds and a MLGP peptide-containing substrate. Cellular target engagement experiments further confirm the Naa50 binding of 4a and demonstrate its selectivity toward related enzymes (Naa10 and Naa60). Addnl. analogs of inhibitor 4a were also evaluated to study the binding mode observed in the cocrystal structures.
Recommanded Product: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.
Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.
Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary