On July 7, 2021, Zhang, Shuai; Xiao, Jun-Zhao; Li, Yan-Bo; Shi, Chang-Yun; Yin, Liang published an article.Synthetic Route of 2567-29-5 The title of the article was Copper(I)-Catalyzed Asymmetric Alkylation of Unsymmetrical Secondary Phosphines. And the article contained the following:
A Cu(I)-catalyzed asym. alkylation of HPAr1Ar2 with alkyl halides is uncovered, which provides an array of P-stereogenic phosphines in generally high yield and enantioselectivity. The electrophilic alkyl halides enjoy a broad substrate scope, including allyl bromides, propargyl bromide, benzyl bromides, and alkyl iodides. Also, 11 unsym. diarylphosphines (HPAr1Ar2) serve as competent pronucleophiles. The present methodol. is also successfully applied to catalytic asym. double and triple alkylation, and the corresponding products were obtained in moderate diastereo- and excellent enantioselectivities. Some 31P NMR experiments indicate that bulky HPPhMes exhibits weak competitively coordinating ability to the Cu(I)-bisphosphine complex, and thus the presence of stoichiometric HPAr1Ar2 does not affect the enantioselectivity significantly. Therefore, the high enantioselectivity in this reaction is attributed to the high performance of the unique Cu(I)-(R,RP)-TANIAPHOS complex in asym. induction. Finally, one monophosphine and two bisphosphines prepared by the present reaction are employed as efficient chiral ligands to afford three structurally diversified Cu(I) complexes, which demonstrates the synthetic utility of the present methodol. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Synthetic Route of 2567-29-5
The Article related to chiral benzyldiarylphosphine sulfide preparation crystal structure, crystal structure chiral benzyldiarylphosphine sulfide bisphosphine copper bridging halide, mol structure chiral benzyldiarylphosphine sulfide bisphosphine copper bridging halide, bisphosphine copper bridging halide cage complex preparation crystal structure and other aspects.Synthetic Route of 2567-29-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary