Miranda, Alexandre S.; Marcos, Paula M.; Ascenso, Jose R.; Robalo, M. Paula; Bonifacio, Vasco D. B.; Berberan-Santos, Mario N.; Hickey, Neal; Geremia, Silvano published an article in 2021, the title of the article was Conventional vs. microwave- or mechanically-assisted synthesis of dihomooxacalix[4]arene phthalimides: NMR, X-ray and photophysical analysis.Product Details of 574-98-1 And the article contains the following content:
Direct O-alkylation of p-tert-Bu dihomooxacalix[4]arene with N-(bromopropyl)- or N-(bromoethyl)phthalimides and K2CO3 in acetonitrile were conducted under conventional heating (reflux) and using microwave irradiation and ball milling methodologies. The reactions afforded mono- and mainly distal di-substituted derivatives in the cone conformation, in a total of eight compounds I [Y1=Y2=Y3=Y4 = H, phthalimidoethyl, phthalimidopropyl]. The compounds I were isolated by column chromatog., and their conformations and the substitution patterns were established by NMR spectroscopy (1H, 13C, COSY and NOESY experiments). The X-ray structures of four dihomooxacalix[4]arene phthalimide derivatives I[Y1=Y2=Y3 = H, Y4 = phthalimidopropyl or phthalimidoethyl; Y1=Y3 = phthalimidopropyl, Y2=Y4 = H; Y1=Y2 = H, Y3=Y4 = phthalimidopropyl] were reported, as well as their photophys. properties. The microwave (MW)-assisted alkylations drastically reduced the reaction times (from days to less than 45 min) and produced higher yields of both 1,3-di-substituted phthalimides I [Y1=Y3 = phthalimidoethyl; Y2=Y4 = H, Y1=Y3 = phthalimidopropyl; Y2=Y4 = H] with higher selectivity. Ball milling did not revealed to be a good method for this kind of reaction. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Product Details of 574-98-1
The Article related to dihomooxacalixarene bromolalkyl phthalimide alkylation microwave, phthalimidoalkoxy dihomooxacalixarene preparation crystal structure, nmr spectroscopy, x-ray diffraction, ball milling, conventional synthesis, dihomooxacalix[4]arenes, electronic absorption and fluorescence studies, microwave irradiation, phthalimide derivatives and other aspects.Product Details of 574-98-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary