On October 15, 2015, Dominique, Romyr; Lopez-Tapia, Francisco Javier; Mertz, Eric; So, Sung-Sau published a patent.Application In Synthesis of 2-Bromo-4-fluoro-5-methylbenzoic acid The title of the patent was Inhibitors of bruton’s tyrosine kinase. And the patent contained the following:
This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient. The experimental process involved the reaction of 2-Bromo-4-fluoro-5-methylbenzoic acid(cas: 1003709-39-4).Application In Synthesis of 2-Bromo-4-fluoro-5-methylbenzoic acid
The Article related to pyridinone phthalazinone preparation brutons tyrosine kinase btk inhibitor antiinflammatory, phthalazinone oxopyridinylbenzyl preparation auto immune disease aberrant bcell proliferation, rheumatoid arthritis treatment antirheumatic pyridinone phthalazinone preparation btk inhibitor and other aspects.Application In Synthesis of 2-Bromo-4-fluoro-5-methylbenzoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary