On May 22, 2014, Dominique, Romyr; Lopez-Tapia, Francisco Javier; Mertz, Eric; So, Sung-Sau published a patent.Recommanded Product: 2-Bromo-4-fluoro-5-methylbenzoic acid The title of the patent was Preparation of substituted pyridinones as inhibitors of bruton’s tyrosine kinase. And the patent contained the following:
The title compounds I [A = (un)substituted unsaturated or partially saturated monocyclic or bicyclic heteroaryl or phenyl; R1 = halo, hydroxyalkyl, alkyl; m = 0-2; R2 = Me, pyrazolyl; n = 0-1; X = a bond, CH2, NHC(O)], useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity, were prepared E.g., a multi-step synthesis of II, starting from 6-tert-butyl-8-fluoro-2H-phthalazin-1-one and 1-bromo-4-chloromethylbenzene, was described. Exemplified compounds I were evaluated for their Btk inhibitory activity (data given). The compounds I are useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds I and at least one carrier, diluent or excipient. The experimental process involved the reaction of 2-Bromo-4-fluoro-5-methylbenzoic acid(cas: 1003709-39-4).Recommanded Product: 2-Bromo-4-fluoro-5-methylbenzoic acid
The Article related to pyridinone phthalazinone preparation bruton’s tyrosine kinase btk inhibitor antiinflammatory, phthalazinone oxopyridinylbenzyl preparation auto immune disease aberrant bcell proliferation, rheumatoid arthritis treatment antirheumatic pyridinone phthalazinone preparation btk inhibitor and other aspects.Recommanded Product: 2-Bromo-4-fluoro-5-methylbenzoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary